Isobel Gamble is a young seamstress carrying generations of secrets when she sets sail from Scotland in the early 1800s with her husband, Edward. An apothecary who has fallen under the spell of opium, his pile of debts have forced them to flee Edinburgh for a fresh start in the New World. But only days after they've arrived in Salem, Edward abruptly joins a departing ship as a medic--leaving Isobel penniless and alone in a strange country. When she meets a young Nathaniel Hawthorne, the two are instantly drawn to each other: he is a man haunted by his ancestors, who sent innocent women to the gallows--while she is an unusually gifted needleworker, troubled by her own strange talents. As the weeks pass and Edward's safe return grows increasingly unlikely, Nathaniel and Isobel grow closer and closer. Interwoven with Isobel and Nathaniel's story is a vivid interrogation of who gets to be a "real" American in the first half of the 19th century, a depiction of the early days of the Underground Railroad in New England, and atmospheric interstitials that capture the long history of "unusual" women being accused of witchcraft.