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A time transect of exomes from a Native American population before and after European contact

Lindo, John (author.). Huerta-Sánchez, Emilia, (author.). Nakagome, Shigeki, (author.). Rasmussen, Morten, (author.). Petzelt, Barbara, (author.). Mitchell, Joycelynn, (author.). Cybulski, Jerome S., (author.). Willerslev, Eske, (author.). DeGiorgio, Michael, (author.). Malhi, Ripan S., (author.).

Available copies

  • 3 of 3 copies available at BC Interlibrary Connect. (Show)
  • 3 of 3 copies available at Prince Rupert Library.

Current holds

0 current holds with 3 total copies.

Location Call Number / Copy Notes Barcode Shelving Location Holdable? Status Due Date
Prince Rupert Library 599.9 Lind (Text) 33294002079762 Adult Non-Fiction Volume hold Available -
Prince Rupert Library NWHC 599.9 Lind (Text) 33294002078236 Northwest History Collection - Non-Circulating Not holdable Available -
Prince Rupert Library Ref 599.9 Lind (Text) 33294002078228 Reference - Non-Circulating Not holdable Available -

Record details

  • Physical Description: 11 pages : illustrations, charts ; 29 cm.
  • Publisher: London, United Kingdom : Nature Research, 2016.

Content descriptions

Summary, etc.: "A major factor for the population decline of Native Americans after European contact has been attributed to infectious disease susceptibility. To investigate whether a pre-existing genetic component contributed to this phenomenon, here we analyse 50 exomes of a continuous population from the Northwest Coast of North America, dating from before and after European contact. We model the population collapse after European contact, inferring a 57% reduction in effective population size. We also identify signatures of positive selection on immune-related genes in the ancient but not the modern group, with the strongest signal deriving from the human leucocyte antigen (HLA) gene HLA-DQA1. The modern individuals show a marked frequency decrease in the same alleles, likely due to the environmental change associated with European colonization, whereby negative selection may have acted on the same gene after contact. The evident shift in selection pressures correlates to the regional European-borne epidemics of the 1800s."--
Subject: Physical anthropology
Evolution (Biology)
Human genetics -- Variation

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